To control intestinal bacterial infection, phage is committed to doing a good job in "intestinal weeding"

Those who pay attention to animal intestinal health know that the barrier function of the intestinal tract includes four parts: physical, chemical, immune and biological. Among them, the physical barrier is composed of the intestinal epithelium with complete structure and function and the tight connection between cells; Mucus, digestive juice secreted by intestinal mucosal epithelial cells and antibacterial substances produced by intestinal parasitic bacteria are chemical barriers; Antibodies such as S-IgA secreted by intestinal mucosal epithelial cells and submucosal lymphoid tissue constitute an immune barrier; Healthy beneficial bacteria in the intestinal tract constitute a biological barrier. Any part of the above damage can lead to the impairment of intestinal barrier function, which seriously affects the health level and production performance of animals.

Therefore, in the process of actual breeding and production, the intestinal tract of animals is often invaded by pathogenic bacteria, resulting in a variety of intestinal diseases and systemic infections (which is more prominent after the comprehensive prohibition of feed resistance). Therefore, the efficient control of intestinal bacterial infection is considered to be the first barrier to protect the intestinal tract. In this regard, it is known as "intestinal weeder" Phages are worth looking forward to.

Bacteriophages have been used to treat bacterial diseases for a hundred years in Eastern Europe, while the national action plan to curb drug resistance of bacteria of animal origin (2017-2020) issued by China has clearly listed bacteriophages as antibiotic substitutes. Bacteriophages are ideal antibiotic substitutes in non resistant and reduced resistance breeding because of their characteristics of "efficient sterilization, safety and no residue". A large number of studies have shown that bacteriophage is a new type of living microbial preparation beneficial to animal health, and each bacterium has its corresponding bacteriophage natural enemies; In addition, phage has the following advantages in application:

1. It is effective against gram-positive, negative and multidrug-resistant bacteria;

2. Specificity;

3. Do not destroy normal flora;

4. Almost no side effects and no residue;

5. It can be widely used in the whole body.