"Small Green Bottle"——Scientific Application of Mucosal Immunization in the Prevention and Control of Avian Influenza

Avian influenza is a kind of poultry infection syndrome caused by type A influenza virus, which seriously threatens the global breeding industry, human health and public health safety. Avian influenza viruses belong to the Orthomyxoviridae family and influenza viruses. Two important proteins embedded in the virus surface envelope-hemagglutinin (HA, 16 species) and neuraminidase (NA, 9 species) divide avian influenza into different Subtype. Avian influenza virus has eight gene segments. When cells are infected with two different influenza virus particles, genetic recombination occurs easily when the virus replicates in the body, forming new strains, which brings great difficulty to the prevention and control of avian influenza.

Mucosa is the body’s main body to resist infection. More than 50% of the body’s lymphatic tissue and 80% of immune cells exist in the mucosal system. Quantitatively speaking, mucosal immunity is the body’s largest immune system and the body’s first line of defense against infection.

1. Features of "Little Green Bottle".
Fast speed: Immune lactic acid bacteria will grow in logarithm within 20 minutes, 4 hours into logarithmic growth, based on basic immunity, quickly promote the body to produce SIgA, compensate for traditional immune deficiency, quickly adjust the balance of mucosal flora, and establish the body's first defense against pathogen invasion Line of defense.

Strong immunity: Increase the secretion of mucosal antibody SIgA by more than 1 times, accounting for more than 80% of the total mucosal antibody. The structure of SIgA dimer contains more antigen binding sites and has stronger ability of neutralizing pathogens and immune elimination.

Comprehensive immunity: The mucosal immune system is widely distributed in the digestive tract, respiratory tract, urogenital tract and other parts, covering humoral immunity and cellular immunity, playing a comprehensive role from local immunity to systemic immunity, and enhancing the immune function of animals. Oral immunization saves time and effort, is safe and efficient.

2. "Little Green Bottle" solves the pain points of the aquaculture industry.
Traditional immune pain point 1: Inducing mucosal antibodies is not ideal. Even if chickens produce high-titer humoral antibodies, they still cannot effectively block the virus from invading the body!
The "little green bottle" focuses on improving the mucosal immune function, effectively blocking influenza viruses on the mucosal surface of the respiratory and digestive tracts, and building the first line of defense against viral infections.

Traditional immunization pain point 2: Traditional avian influenza vaccine has a long immunization period (2-3 weeks), a high incidence rate during this period, and a high breeding risk!
The "little green bottle" quickly promotes the production of mucosal antibody SIgA, which can effectively make up for the blank period of humoral immunity.

Traditional immune pain point 3: Traditional avian flu vaccines are helpless against viruses that adhere to the surface of the respiratory tract and invade epithelial cells, causing diseased animals to continue to carry the virus and become a source of infection in chickens!
By producing SIgA, the "little green bottle" effectively eliminates and neutralizes the virus on the mucosal surface and epithelial layer, shortens the body's detoxification time, and eliminates the source of virus transmission in the group.

Traditional immune pain point 4: At this stage of poultry farming, immunosuppressive factors are superimposed, influenza virus mutates, and the immune burden is heavy, combined with omissions and immunizations, resulting in low antibody levels in chickens and weak immune protection!
The "little green bottle" is used orally, highly effective and safe, and comprehensively enhances the immune function of the animal's body and effectively responds to mutant virus strains.

Traditional immunization pain point five: The biggest problem is that the number of immunizations in meat and poultry farming is small or not. The number of immunizations is not enough to induce enough antibodies, and the basic line of protection cannot be reached!
The "little green bottle" mucosal immunity + humoral immunity is the best immune combination for the prevention and control of avian influenza!